As the virus continues to mutate, T-cell recognition of newer variants may be lost, the researchers cautioned. That could lead to decreasing overall protection by the immune system.
Despite the fact that T-cells were still able to recognize parts of the spike protein, called epitopes, including those in the omicron variant, recognition was worse in seven of 10 epitopes that were mutated in different variants, the study found.
“Our paper shows that although most people have a diverse T-cell response against the virus, some responses are less effective against omicron. As further variants of concern are identified we will need to consider carefully how new viral mutations affect T-cell recognition,” said lead study author Heather Long, an associate professor in the Institute of Immunology and Immunotherapy at the University of Birmingham in England.
“The vaccines currently in use are still vital to protect us from COVID-19,” Graham Taylor, an associate professor in the institute, added in a university news release. “Should SARS-CoV-2 continue to mutate to evade the immune system, our findings will help researchers to develop new vaccines better suited to those variants.”
As part of the study, researchers tested CD4+ T-cells collected early in the pandemic from health care workers who were infected with COVID-19.
The findings were published Dec. 1 in Nature Immunology. The study was funded by the National Institute for Health and Care Research, the research partner of the National Health Service in the United Kingdom.
The U.S. Centers for Disease Control and Prevention has more on COVID-19.
SOURCE: University of Birmingham, news release, Dec. 1, 2022
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