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A half-century-old diabetes drug appears to help treat bipolar disorder by reversing patients’ insulin resistance, according to a small-scale clinical trial. Bipolar patients who responded to the drug metformin experienced improvement in their mood disorder as their insulin resistance decreased, said lead researcher Dr. Cynthia Calkin, an associate professor of psychiatry at Dalhousie University in…  read on >  read on >

They are called “forever chemicals” because they linger in the human body and can contribute to the risk of everything from cancer to childhood obesity. Now, new research on per- and polyfluoroalkyl substances (PFAS) finds they also exact a huge financial toll, costing the U.S. health system billions every year. “Our findings add to the…  read on >  read on >

That phrase “no pain, no gain” might truly apply to people with peripheral artery disease (PAD), a new study finds. Researchers found that people with PAD who walked at pace that caused discomfort or even pain improved their walking ability. “Exercise that induces leg pain is beneficial, though difficult,” said senior author Dr. Mary McDermott,…  read on >  read on >

Middle-aged people could add years to their lives just by getting off the couch and going for a walk every day — though it wouldn’t hurt to do even more, a large new study suggests. The researchers followed over 100,000 Americans for decades and found what many have shown before: People who exercise as much…  read on >  read on >